ABCB7 Polyclonal Antibody

• Background:

  The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD14 that are known to be present in the human peroxisome membrane (1) . All four proteins are ABC half-transporters, which dimerize to form an active transporter (1) . A mutation in the ABCD1 causes X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage (2,3) . ABCD2 in mouse, is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD (4) . The peroxisomal membrane comprises 2 quantitatively major proteins, PMP22 and ABCD3 (5) . ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors (5) . ABCD4 localizes to peroxisomes (1) . The genes which encode ABCD14 map to human chromosome Xq28, 12q11-q12, 1p22-p21 and 14q24.3, respectively (3,68) . ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol and maps to human chromosome Xq13.1-q13.3 (9) .

• Synonyms:

  ABC transporter 7 protein; ABC7; Abcb7; ABCB7_HUMAN; ASAT; Atm1p; ATP binding cassette 7; ATP binding cassette sub family B MDR/TAP member 7; ATP binding cassette sub family B member 7; ATP binding cassette sub family B member 7 mitochondrial; ATP binding cassette transporter 7; ATP-binding cassette sub-family B member 7; ATP-binding cassette transporter 7; EST140535; MDR7; mitochondrial; Multidrug resistance protein 7; P-glycoprotein 7; PGP7.

• Gene ID:

  22

• Cellular Locus:

  Cytoplasm, Cell membrane

• Host:

  Rabbit

• Immunogen:

  201-300/752

• Target:

  ABCB7

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human ABCB7

• Applications:

  ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL:

  22

• Predicted Cross Reactivity:

  Human, Mouse, Rat, Dog, Sheep, Pig, Rabbit