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Propafenone

CAT: 0957-S5789-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S5789-01Size:5 mg
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Description
Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.Propafenone can be used to induce animal models of Heart Failure.
CAS Number
54063-53-5
Synonyms
SA-79
Target
Sodium Channel
Activity
Transmembrane Transporters
Molecular Formula
C21H27NO3
Storage Conditions
3 years -20°C powder

Chemical Information

Propafenone

Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary alcohol, a secondary amino compound and an aromatic ketone. It is a conjugate base of a propafenone(1+).

CAS Number54063-53-5
PubChem CID4932
IUPAC Name1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
Molecular FormulaC21H27NO3
Molecular Weight341.4
XLogP3.3
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Heavy Atom Count25
Formal Charge0
Complexity368
SMILES
CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
InChI
InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
InChIKey
JWHAUXFOSRPERK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Propafenone
CAS: 54063-53-5
CID: 4932
Formula: C21H27NO3
MW: 341.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight341.4
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass341.19909372
Monoisotopic Mass341.19909372
Topological Polar Surface Area58.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity368
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
TRC-P767403-500MGPropafenone
287057-01Propafenone hydrochloride
HY-B0432A-01Propafenone (hydrochloride)
T12811-01(S) -Propafenone
RM-P161619-01(R) -Propafenone
TRC-P757496-5MG(S)-Propafenone

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