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Eltrombopag

CAT: 0957-S4502-03Size: 50 mgDry Ice: YesHazardous: No
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CAT#:0957-S4502-03Size:50 mg
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Description
Eltrombopag (SB-497115), a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP) .
CAS Number
496775-61-2
Synonyms
SB-497115
Target
TpoR
Activity
Immunology & Inflammation
Molecular Formula
C25H22N4O4
Storage Conditions
2 years -80 in solvent

Chemical Information

Eltrombopag

Eltrombopag is a hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts). It has a role as a xenobiotic and a thrombopoietin receptor agonist. It is a member of benzoic acids, a member of hydrazines and a member of pyrazoles.

CAS Number496775-61-2
PubChem CID135449332
IUPAC Name3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid
Molecular FormulaC25H22N4O4
Molecular Weight442.5
XLogP5.4
Topological Polar Surface Area115
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity812
SMILES
CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
InChI
InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)
InChIKey
SVOQIEJWJCQGDQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Eltrombopag
CAS: 496775-61-2
CID: 135449332
Formula: C25H22N4O4
MW: 442.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight442.5
XLogP35.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass442.16410520
Monoisotopic Mass442.16410520
Topological Polar Surface Area115 Ų
Heavy Atom Count33
Formal Charge0
Complexity812
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B2159-500Eltrombopag

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