SNX5 Polyclonal Antibody

• Background:

  Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking (1) . SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor (2,3) . SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain (4) . These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases (2) . These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes (1,5) . The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors (2,6) .

• Synonyms:

  0910001N05Rik; 1810032P22Rik; AU019504; D2Ertd52e; FLJ10931; OTTHUMP00000030340; OTTHUMP00000062927; OTTMUSP00000003367; OTTMUSP00000003368; RP11-504H3.2; RP23-35E16.2; snoRNA MBI-43; SNX 5; SNX5; SNX5_HUMAN; Sorting nexin 5; Sorting nexin-5.

• Gene ID:

  27131

• Cellular Locus:

  Cytoplasm, Cell membrane

• Host:

  Rabbit

• Immunogen:

  2-75/404

• Target:

  SNX5

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human SNX5

• Applications:

  WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL:

  27131

• Predicted Cross Reactivity:

  Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit