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KDM4B Polyclonal Antibody

CAT: 0498-bs-12198RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-12198RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
JMJD2B is a 1,064 amino acid protein encoded by the human gene JMJD2B. JMJD2B belongs to the JMJD2B histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. The two Tudor domains recognize and bind methylated histones and have an interdigitated structure; the unusual fold is required for its ability to bind methylated histone tails. JMJD2B is a histone demethylase that specifically demethylates Lys 9 residues of Histone H3, thereby playing a role in histone code. It does not demethylate Histone H3 Lys 4, H3 Lys 27, H3 Lys 36 or H4 Lys 20, however, and is only able to demethylate trimethylated H3 Lys-9 and has weaker activity than JMJD2A, JMJD2C and JMJD2D. JMJD2B demethyl-ation of Lysine residues will generate formaldehyde and succinate. JMJD2B is a ubiquitously expressed nuclear protein.
Synonyms
JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; JmjC domain-containing histone demethylation protein 3A; Jumonji domain containing protein 2B; KIAA0876; Lysine-specic demethylase 4B; KDM4B_HUMAN.
Gene ID
23030
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
51-150/1096
Target
KDM4B
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human JMJD2B/KDM4B
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
23030
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow

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