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Dooku1

CAT: 0957-S2953-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-S2953-03Size:25 mg
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Description
Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca2+-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.
CAS Number
2253744-54-4
Target
Mechanosensitive Channel
Activity
Transmembrane Transporters
Molecular Formula
C13H9Cl2N3OS
Storage Conditions
3 years -20°C powder

Chemical Information

Dooku1
CAS Number2253744-54-4
PubChem CID137321150
IUPAC Name2-[(2,6-dichlorophenyl)methylsulfanyl]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
Molecular FormulaC13H9Cl2N3OS
Molecular Weight326.2
XLogP3.8
Topological Polar Surface Area80
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity316
SMILES
C1=CC(=C(C(=C1)Cl)CSC2=NN=C(O2)C3=CC=CN3)Cl
InChI
InChI=1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2
InChIKey
MNPOBXLPCWFONX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dooku1
CAS: 2253744-54-4
CID: 137321150
Formula: C13H9Cl2N3OS
MW: 326.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight326.2
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass324.9843385
Monoisotopic Mass324.9843385
Topological Polar Surface Area80 Ų
Heavy Atom Count20
Formal Charge0
Complexity316
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A9047-5Dooku1
A18409-5Dooku1 5mg
A18409-25Dooku1 25mg
A18409-2Dooku1 2mg
A18409-10Dooku1 10mg
A18409-100Dooku1 100mg
A18409-50Dooku1 50mg
A18409-1Dooku1 1mg
A18409-10mM-DDooku1 10mM * 1mL in DMSO

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