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MPEP

CAT: 0957-S2809-01Size: 10 mgDry Ice: YesHazardous: No
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CAT#:0957-S2809-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
CAS Number
96206-92-7
Target
GluR
Activity
Neuronal Signaling
Molecular Formula
C14H11N
Storage Conditions
2 years -80 in solvent

Chemical Information

Mpep

2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as an anxiolytic drug and a metabotropic glutamate receptor antagonist. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.

CAS Number96206-92-7
PubChem CID3025961
IUPAC Name2-methyl-6-(2-phenylethynyl)pyridine
Molecular FormulaC14H11N
Molecular Weight193.24
XLogP3.3
Topological Polar Surface Area12.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count15
Formal Charge0
Complexity251
SMILES
CC1=NC(=CC=C1)C#CC2=CC=CC=C2
InChI
InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
InChIKey
NEWKHUASLBMWRE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mpep
CAS: 96206-92-7
CID: 3025961
Formula: C14H11N
MW: 193.24
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight193.24
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass193.089149355
Monoisotopic Mass193.089149355
Topological Polar Surface Area12.9 Ų
Heavy Atom Count15
Formal Charge0
Complexity251
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1628-10MPEP
HY-14609-01MPEP (Hydrochloride)
456629-01MPEP Hydrochloride
abx282936-01MPEP HCl

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