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GDAP1 Polyclonal Antibody

CAT: 0498-bs-11725RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-11725RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.
Synonyms
Ganglioside induced dferentiation associated protein 1; Ganglioside-induced dferentiation-associated protein 1; GDAP1; GDAP1_HUMAN.
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
151-230/358
Target
GDAP1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human GDAP1
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit, Orangutan