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Setidegrasib (ASP3082)

CAT: 0957-E4757-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-E4757-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Setidegrasib (KRAS G12D inhibitor 17, ASP3082) is a PROTAC-based KRAS degrader (DC50 = 37 nM) that specifically targets G12D-mutated KRAS protein for degradation. It demonstrates potent inhibition of p-ERK, p-AKT, and p-S6 signaling pathways in AsPC-1 cells. The compound shows significant antitumor efficacy across multiple murine xenograft models. Setidegrasib serves as a research tool for investigating KRAS (G12D) -driven solid tumors. (Blue: VHL ligand ; Black: linker ; Pink: G12D-targeting moiety) .
CAS Number
2821793-99-9
Synonyms
ASP-3082; KRAS G12D inhibitor 17
Target
PROTAC
Activity
Others
Molecular Formula
C60H65FN12O7S

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