NR2E3 Polyclonal Antibody

• Background:

  Photoreceptor-specific nuclear receptor, also known as NR2E3 or PNR, belongs to a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E3 has a role in regulating the signaling pathway elemental to the photoreceptor cell function and in regulating pathways involved in embryonic development. NR2E3 is an eye specific nuclear protein found in the outer nuclear layer of the adult retina (where the nuclei of cone and rod photoreceptors are located) . Defects in this gene encoding for the protein, which localizes to chromosome 15q22.32, cause enhanced S cone syndrome.

• Synonyms:

  ESCS; ESCS; NR2 E3; Nr2e3; NR2E3_HUMAN; Nuclear receptor subfamily 2 group E member 3; Photoreceptor specic nuclear receptor; Photoreceptor-specic nuclear receptor antibody PNR; Rd 7; rd7; Retina specic nuclear receptor; Retina-specic nuclear receptor; Retinal degeneration 7; Retinal degeneration 7; RNR; RP37.

• Cellular Locus:

  Nucleus

• Host:

  Rabbit

• Immunogen:

  1-100/410

• Target:

  NR2E3

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human NR2E3

• Applications:

  WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Predicted Cross Reactivity:

  Human, Mouse, Rat, Cow, Sheep