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Zotatifin

CAT: 0957-S8994Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-S8994Size:1 mg
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Description
Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.
CAS Number
2098191-53-6
Synonyms
EFT226
Target
EIF
Activity
Cell Cycle
Molecular Formula
C28H29N3O5

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