T-5224

CAT: 0957-S8966-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0957-S8966-01Size:5 mg

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Description

T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP) -1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.

CAS Number

530141-72-1

Target

MMP

Activity

Proteases

Molecular Formula

C29H27NO8

Storage Conditions

3 years -20°C powder

Chemical Information

T-5224

T-5224 is an investigational drug developed to treat Sepsis-induced Acute Kidney Injury. It's mechanism of action is to inhibit c-Fos/activator protein-1.

CAS Number	530141-72-1
PubChem CID	23626877
IUPAC Name	3-[5-(4-cyclopentyloxy-2-hydroxybenzoyl)-2-[(3-oxo-1,2-benzoxazol-6-yl)methoxy]phenyl]propanoic acid
Molecular Formula	C29H27NO8
Molecular Weight	517.5
XLogP	5.1
Topological Polar Surface Area	131
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Heavy Atom Count	38
Formal Charge	0
Complexity	844

SMILES

C1CCC(C1)OC2=CC(=C(C=C2)C(=O)C3=CC(=C(C=C3)OCC4=CC5=C(C=C4)C(=O)NO5)CCC(=O)O)O

InChI

InChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33)

InChIKey

DALCQQSLNPLQFZ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 530141-72-1

CID: 23626877

Formula: C29H27NO8

MW: 517.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	517.5
XLogP3	5.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	517.17366682
Monoisotopic Mass	517.17366682
Topological Polar Surface Area	131 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	844
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
9546-5	T-5224
7317/50	T 5224
A14406-50	T-5224 50mg
A14406-2	T-5224 2mg

T-5224

Chemical Information

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