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A-485

CAT: 0957-S8740-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0957-S8740-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.
CAS Number
1889279-16-6
Target
Histone Acetyltransferase
Activity
Epigenetics
Molecular Formula
C25H24F4N4O5
Storage Conditions
3 years -20°C powder

Chemical Information

A-485

A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively.

CAS Number1889279-16-6
PubChem CID118958122
IUPAC NameN-[(4-fluorophenyl)methyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide
Molecular FormulaC25H24F4N4O5
Molecular Weight536.5
XLogP3.3
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity941
SMILES
C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O
InChI
InChI=1S/C25H24F4N4O5/c1-14(25(27,28)29)32(12-15-3-5-17(26)6-4-15)20(34)13-33-21(35)24(38-23(33)37)10-9-16-11-18(7-8-19(16)24)31-22(36)30-2/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,30,31,36)/t14-,24+/m0/s1
InChIKey
VRVJKILQRBSEAG-LFPIHBKWSA-N
Chemical Structure
2D Structure
2D structure of A-485
CAS: 1889279-16-6
CID: 118958122
Formula: C25H24F4N4O5
MW: 536.5
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight536.5
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass536.16828253
Monoisotopic Mass536.16828253
Topological Polar Surface Area108 Ų
Heavy Atom Count38
Formal Charge0
Complexity941
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4653-5A-485
BA166476-01A 485
A16830-50A-485 50mg

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