NCB-0846

CAT: 0957-S8392-05Size: 1 gDry Ice: YesHazardous: No

1 / 1

CAT#:0957-S8392-05Size:1 g

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase, MAP4K7) with an IC50 value of 21 nM.

CAS Number

1792999-26-8

Target

Wnt/beta-catenin

Activity

Cytoskeletal Signaling

Molecular Formula

C21H21N5O2

Storage Conditions

2 years -80 in solvent

Chemical Information

Cis-4-{[2-(1h-Benzimidazol-5-Ylamino)quinazolin-8-Yl]oxy}cyclohexanol

CAS Number	1792999-26-8
PubChem CID	91801204
IUPAC Name	4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol
Molecular Formula	C21H21N5O2
Molecular Weight	375.4
XLogP	3.6
Topological Polar Surface Area	96
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	28
Formal Charge	0
Complexity	515

SMILES

C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5

InChI

InChI=1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,26)

InChIKey

FYWRWBSYRGSWIQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1792999-26-8

CID: 91801204

Formula: C21H21N5O2

MW: 375.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	375.4
XLogP3	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	375.16952493
Monoisotopic Mass	375.16952493
Topological Polar Surface Area	96 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	515
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
S1718-1g	Adefovir Dipivoxil (GS 0840)
S1718-01	Adefovir Dipivoxil (GS 0840)
S1718-100mg	Adefovir Dipivoxil (GS 0840)
S1718-50mg	Adefovir Dipivoxil (GS 0840)
S1718-10mM/1mL	Adefovir Dipivoxil (GS 0840)
S6950-5mg	PRE-084 hydrochloride
S6950-01	PRE-084 hydrochloride
S6950-25mg	PRE-084 hydrochloride

Alternative Products

Catalog	Name
BA6478-100	NCB-0846
HY-100830R	NCB-0846 (Standard)
A20535-25	NCB-0846 25mg
A20535-5	NCB-0846 5mg
A20535-1	NCB-0846 1mg

NCB-0846

Chemical Information

Related Products

Alternative Products

Popular Products