BMS-986142

CAT: 0957-S8381-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0957-S8381-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK with an IC50 of 0.5 nM. In a panel of 384 kinases, only five kinases were inhibited by BMS-986142 with less than 100-fold selectivity for BTK (TEC, ITK, BLK, TXK and BMX) .

CAS Number

1643368-58-4

Target

BTK

Activity

Protein Tyrosine Kinase

Molecular Formula

C32H30F2N4O4

Storage Conditions

3 years -20°C powder

Chemical Information

Bms-986142

BMS-986142 is under investigation in clinical trial NCT02880670 (Pharmacokinetics and Metabolism Study of Radiolabeled BMS-986142 in Healthy Male Subjects).

CAS Number	1643368-58-4
PubChem CID	86582336
IUPAC Name	(7S)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide
Molecular Formula	C32H30F2N4O4
Molecular Weight	572.6
XLogP	4.4
Topological Polar Surface Area	120
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	42
Formal Charge	0
Complexity	1090

SMILES

CC1=C(C=CC=C1N2C(=O)C3=C(C(=CC=C3)F)N(C2=O)C)C4=C(C=C(C5=C4C6=C(N5)C[C@H](CC6)C(C)(C)O)C(=O)N)F

InChI

InChI=1S/C32H30F2N4O4/c1-15-17(7-6-10-24(15)38-30(40)19-8-5-9-21(33)28(19)37(4)31(38)41)25-22(34)14-20(29(35)39)27-26(25)18-12-11-16(32(2,3)42)13-23(18)36-27/h5-10,14,16,36,42H,11-13H2,1-4H3,(H2,35,39)/t16-/m0/s1

InChIKey

ZRYMMWAJAFUANM-INIZCTEOSA-N

Chemical Structure

2D Structure

CAS: 1643368-58-4

CID: 86582336

Formula: C32H30F2N4O4

MW: 572.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	572.6
XLogP3	4.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	572.22351178
Monoisotopic Mass	572.22351178
Topological Polar Surface Area	120 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	1090
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
E0472	BMS-986122
E0472-5mg	BMS-986122
S9691-5mg	BMS-986158
E6404-25mg	BMS-986449
S9691-01	BMS-986158
S9814-01	BMS-986202
E0498	BMS-986176
S9691-10mM/1mL	BMS-986158
E6404-01	BMS-986449
E6404-100mg	BMS-986449

Alternative Products

Catalog	Name
BA8836-25	BMS-986142
A19993-200	BMS-986142 200mg
A19993-100	BMS-986142 100mg
A19993-50	BMS-986142 50mg
A19993-10	BMS-986142 10mg
A19993-500	BMS-986142 500mg
A19993-1	BMS-986142 1mg
A19993-25	BMS-986142 25mg
A19993-5	BMS-986142 5mg

BMS-986142

Chemical Information

Related Products

Alternative Products

Popular Products