GSK591

CAT: 0957-S8111-02Size: 10 mm/ 1 mLDry Ice: YesHazardous: No

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CAT#:0957-S8111-02Size:10 mm/ 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSK591 (EPZ015866, GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 4 nM.

CAS Number

1616391-87-7

Synonyms

EPZ015866, GSK3203591

Target

Histone Methyltransferase

Activity

Epigenetics

Molecular Formula

C22H28N4O2

Storage Conditions

2 years -80 in solvent

Chemical Information

Gsk591

GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5).

CAS Number	1616391-87-7
PubChem CID	117072552
IUPAC Name	2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide
Molecular Formula	C22H28N4O2
Molecular Weight	380.5
XLogP	2.3
Topological Polar Surface Area	77.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Heavy Atom Count	28
Formal Charge	0
Complexity	513

SMILES

C1CC(C1)NC2=NC=CC(=C2)C(=O)NC[C@@H](CN3CCC4=CC=CC=C4C3)O

InChI

InChI=1S/C22H28N4O2/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28)/t20-/m0/s1

InChIKey

TWKYXZSXXXKKJU-FQEVSTJZSA-N

Chemical Structure

2D Structure

CAS: 1616391-87-7

CID: 117072552

Formula: C22H28N4O2

MW: 380.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	380.5
XLogP3	2.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	380.22122615
Monoisotopic Mass	380.22122615
Topological Polar Surface Area	77.5 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	513
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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S8261-5mg	GSK583
S8261-01	GSK583
S7802-01	GSK199
S7898-01	GSK621
S7898-25mg	GSK621
S7898-1g	GSK621
S8169-2mg	GSK481
S8169-25mg	GSK481

Alternative Products

Catalog	Name
T6853-01	GSK591
A14374-25	GSK591 25mg
A14374-1	GSK591 1mg
HY-100235R	GSK591 (Standard)
MBS131308	EPZ015866 (GSK591)
HY-100235A	GSK591 (hydrochloride)
A14374-50	GSK591 50mg
A14374-10	GSK591 10mg
A14374-500	GSK591 500mg
A14374-100	GSK591 100mg

GSK591

Chemical Information

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