Products for Research Use Only
RegisterLogin

FRAX486

CAT: 0957-S7807-02Size: 10 mm/ 1 mLDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0957-S7807-02Size:10 mm/ 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
CAS Number
1232030-35-1
Target
PAK
Activity
Cytoskeletal Signaling
Molecular Formula
C25H23Cl2FN6O
Storage Conditions
2 years -80 in solvent

Chemical Information

Frax486
CAS Number1232030-35-1
PubChem CID68060125
IUPAC Name6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC25H23Cl2FN6O
Molecular Weight513.4
XLogP4.8
Topological Polar Surface Area73.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity783
SMILES
CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)Cl)Cl)NC4=CC(=C(C=C4)N5CCNCC5)F
InChI
InChI=1S/C25H23Cl2FN6O/c1-2-34-23-15(11-19(24(34)35)18-5-3-16(26)12-20(18)27)14-30-25(32-23)31-17-4-6-22(21(28)13-17)33-9-7-29-8-10-33/h3-6,11-14,29H,2,7-10H2,1H3,(H,30,31,32)
InChIKey
DHKFOIHIUYFSOF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Frax486
CAS: 1232030-35-1
CID: 68060125
Formula: C25H23Cl2FN6O
MW: 513.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight513.4
XLogP34.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass512.1294429
Monoisotopic Mass512.1294429
Topological Polar Surface Area73.4 Ų
Heavy Atom Count35
Formal Charge0
Complexity783
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B6165-10FRAX486
A13691-5FRAX486 5mg
A13691-10FRAX486 10mg
A13691-2FRAX486 2mg
A13691-100FRAX486 100mg
A13691-50FRAX486 50mg
A13691-25FRAX486 25mg

Popular Products