Products for Research Use Only
RegisterLogin

Sprouty1 Polyclonal Antibody

CAT: 0498-bs-11216RSize: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-11216RSize:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich C-terminal domain with their Drosophila counterparts. Both Sprouty 1 and 2 are anchored to membranes by palmitoylation, associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on Serine residues. Upon stimulation, a subset is recruited to the leading edge of the plasma membrane. Sprouty 2 can associate with c-Cbl, a down regulator of RTK signaling, and inhibits the activities of several growth factors. Sprouty 2 also functions as a negative regulator of embryonic lung morphogenesis and growth. The well-conserved C-terminus of Sprouty contains two domains which are necessary for Sprouty 2 co-localization with microtubules and translocation to membrane ruffles. In addition, the C-terminus is required for the inhibition of cell migration and proliferation. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.
Synonyms
Sprouty 1; Sprouty-1; hSPRY1; Protein sprouty homolog 1; Sprouty homolog 1 antagonist of FGF signaling; Sprouty homolog 1; Spry-1; Spry1; SPY1_HUMAN.
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
221-319/319
Target
Sprouty1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Sprouty1
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Pig, Horse, Chicken

Related Products

CatalogName
bsm-61880R-TRSprouty 4 Recombinant Antibody
bsm-61880R-01Sprouty 4 Recombinant Antibody
bsm-61798R-01Sprouty 2 Recombinant Antibody
bsm-61798R-TRSprouty 2 Recombinant Antibody
bsm-61798R-PerCP-01Sprouty 2 Recombinant Antibody, PerCP Conjugated
bsm-61798R-APC-01Sprouty 2 Recombinant Antibody, APC Conjugated
bsm-61880R-Cy3-01Sprouty 4 Recombinant Antibody, Cy3 Conjugated
bsm-61880R-RBITC-TRSprouty 4 Recombinant Antibody, RBITC Conjugated
bsm-61880R-PerCP-TRSprouty 4 Recombinant Antibody, PerCP Conjugated
bsm-61880R-Biotin-TRSprouty 4 Recombinant Antibody, Biotin Conjugated

Alternative Products

CatalogName
GTR18203914Sprouty1 Polyclonal Antibody
GTR17744632-01Sprouty1 Rabbit Polyclonal Antibody
TMAB-13139-01Anti-Sprouty1 Polyclonal Antibody
GTR17755432Sprouty1 Rabbit Polyclonal Antibody (HRP)
GTR17767898Sprouty1 Rabbit Polyclonal Antibody (AP)
GTR17731794Sprouty1 Rabbit Polyclonal Antibody (Biotin)
SL11216R-01Rabbit Anti-Sprouty1 antibody
APR00460GPolyclonal Spt16 polyclonal antibody
APG01659GPolyclonal AKR1B10 Polyclonal Antibody
APR11188GPolyclonal Rtf1 polyclonal antibody

Popular Products