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Leptomycin B

CAT: 0957-S7580-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-S7580-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
CAS Number
87081-35-4
Synonyms
LMB, CI 940, Elactocin, Mantuamycin, NSC 364372
Target
CRM1
Activity
Transmembrane Transporters
Molecular Formula
C33H48O6
Storage Conditions
3 years -20°C powder

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