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LDN-193189 2HCl

CAT: 0957-S7507-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0957-S7507-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CAS Number
1435934-00-1
Synonyms
DM-3189 2HCl
Target
TGF-beta/Smad
Activity
TGF-beta/Smad
Molecular Formula
C25H24Cl2N6
Storage Conditions
2 years -80 in solvent

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