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GSK2606414

CAT: 0957-S7307-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0957-S7307-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.
CAS Number
1337531-36-8
Target
PERK
Activity
Apoptosis
Molecular Formula
C24H20F3N5O
Storage Conditions
2 years -80 in solvent

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