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UNC1999

CAT: 0957-S7165-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0957-S7165-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.
CAS Number
1431612-23-5
Target
Histone Methyltransferase
Activity
Epigenetics
Molecular Formula
C33H43N7O2
Storage Conditions
2 years -80 in solvent

Alternative Products

CatalogName
2449-5UNC1999
TBI4542-25MGUNC1999, Methyltransferase inhibitor
217350Ezh2/Ezh1 Inhibitor, UNC1999 (Enhancer of Zested Homolog 1 Inhibitor, 1-Isopropyl-6- (6- (4-isopropylpiperazin-1-yl) pyridin-3-yl) -N- ((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl) methyl) -1H-indazole-4-carboxamide, Ezh1 Inhibitor, Ezh2 Inhibitor IV, HMTase Inhibitor XII, Histone Lysine Methyltransferase XII, Enhancer of Zested Homolog 2 Inhibitor IV)

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