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LY2874455

CAT: 0957-S7057-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0957-S7057-01Size:5 mg
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Description
LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.
CAS Number
1254473-64-7
Target
FGFR
Activity
Protein Tyrosine Kinase
Molecular Formula
C21H19Cl2N5O2
Storage Conditions
2 years -80 in solvent

Chemical Information

Ly-2874455

LY2874455 has been used in trials studying the treatment of Advanced Cancer.

CAS Number1254473-64-7
PubChem CID46944259
IUPAC Name2-[4-[(E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Molecular FormulaC21H19Cl2N5O2
Molecular Weight444.3
XLogP3.5
Topological Polar Surface Area88.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity576
SMILES
C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3/C=C/C4=CN(N=C4)CCO
InChI
InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
InChIKey
GKJCVYLDJWTWQU-CXLRFSCWSA-N
Chemical Structure
2D Structure
2D structure of Ly-2874455
CAS: 1254473-64-7
CID: 46944259
Formula: C21H19Cl2N5O2
MW: 444.3
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight444.3
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass443.0915803
Monoisotopic Mass443.0915803
Topological Polar Surface Area88.9 Ų
Heavy Atom Count30
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19164167-01LY2874455

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