CD45 Polyclonal Antibody

• Background :

  Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity) . Dephosphorylates LYN, and thereby modulates LYN activity.

• Synonyms :

  Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, Lymphocyte antigen 5, L-CA, Ly-5, T200

• Swiss Prot :

  P06800

• Cellular Locus :

  Cell membrane

• Host :

  Rabbit

• Cross Reactivity :

  Mouse, Rat

• Immunogen :

  451-550/1291

• Target :

  CD45

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from mouse CD45

• Applications :

  FCM

• Purification :

  Purified by Protein A.

• Concentration :

  1µg/µl

• Dilution :

  FCM (1:20-100)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.