CD45 Polyclonal Antibody

• Background:

  Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity) . Dephosphorylates LYN, and thereby modulates LYN activity.

• Synonyms:

  Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, Lymphocyte antigen 5, L-CA, Ly-5, T200

• Swiss Prot:

  P06800

• Cellular Locus:

  Cell membrane

• Host:

  Rabbit

• Cross Reactivity:

  Mouse, Rat

• Immunogen:

  451-550/1291

• Target:

  CD45

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from mouse CD45

• Applications:

  FCM

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  FCM (1:20-100)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.