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HSP27 inhibitor J2

CAT: 0957-S3404-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S3404-01Size:5 mg
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Description
HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which induces abnormal HSP27 dimers formation and suppresses the generation of HSP27 giant polymers, inhibiting the chaperone role of HSP27 and diminishing its cellular protective function. HSP27 inhibitor J2 (J2) enhances the antiproliferative activity of 17-AAG and increases the sensitivity of cisplatin-induced lung cancer cell growth inhibition.
CAS Number
2133499-85-9
Synonyms
J2
Target
HSP (HSP90)
Activity
Cytoskeletal Signaling
Molecular Formula
C13H12O4S

Chemical Information

HSP27 inhibitor J2
CAS Number2133499-85-9
PubChem CID135384973
IUPAC Name5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)chromen-4-one
Molecular FormulaC13H12O4S
Molecular Weight264.30
XLogP1.6
Topological Polar Surface Area81.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count18
Formal Charge0
Complexity381
SMILES
CC1=CC(=O)C2=C(C=C(C=C2O1)OCC3CS3)O
InChI
InChI=1S/C13H12O4S/c1-7-2-10(14)13-11(15)3-8(4-12(13)17-7)16-5-9-6-18-9/h2-4,9,15H,5-6H2,1H3
InChIKey
VDCWAGBPDCXRDU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of HSP27 inhibitor J2
CAS: 2133499-85-9
CID: 135384973
Formula: C13H12O4S
MW: 264.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight264.30
XLogP31.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass264.04563003
Monoisotopic Mass264.04563003
Topological Polar Surface Area81.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity381
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
S3404-100mgHSP27 inhibitor J2
A18874-100HSP27 inhibitor J2 100mg
A18874-25HSP27 inhibitor J2 25mg
A18874-10HSP27 inhibitor J2 10mg
A18874-2HSP27 inhibitor J2 2mg
A18874-5HSP27 inhibitor J2 5mg
A18874-1HSP27 inhibitor J2 1mg
A18874-50HSP27 inhibitor J2 50mg
A18874-10mM-DHSP27 inhibitor J2 10mM * 1mL in DMSO
319640-01HSP27

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