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Rivaroxaban

CAT: 0957-S3002-02Size: 10 mm/ 1 mLDry Ice: YesHazardous: No
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CAT#:0957-S3002-02Size:10 mm/ 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rivaroxaban is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM) .
CAS Number
366789-02-8
Synonyms
BAY 59-7939
Target
Factor Xa
Activity
Metabolism
Molecular Formula
C19H18ClN3O5S
Storage Conditions
2 years -80 in solvent

Chemical Information

Rivaroxaban

Rivaroxaban is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-chlorothiophene-2-carboxylic acid with the amino group of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. An anticoagulant used for prophylaxis of venous thromboembolism in patients with knee or hip replacement surgery. It has a role as an anticoagulant and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a lactam, a member of thiophenes, a monocarboxylic acid amide, an organochlorine compound, a member of morpholines, an oxazolidinone and an aromatic amide.

CAS Number366789-02-8
PubChem CID9875401
IUPAC Name5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide
Molecular FormulaC19H18ClN3O5S
Molecular Weight435.9
XLogP2.5
Topological Polar Surface Area116
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity645
SMILES
C1COCC(=O)N1C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl
InChI
InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
InChIKey
KGFYHTZWPPHNLQ-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of Rivaroxaban
CAS: 366789-02-8
CID: 9875401
Formula: C19H18ClN3O5S
MW: 435.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight435.9
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass435.0655696
Monoisotopic Mass435.0655696
Topological Polar Surface Area116 Ų
Heavy Atom Count29
Formal Charge0
Complexity645
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A4338-10Rivaroxaban
TRC-R590730-250MG(±)-Rivaroxaban

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