Dacomitinib

CAT: 0957-S2727-01Size: 5 mgDry Ice: YesHazardous: No

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CAT#:0957-S2727-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Dacomitinib is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.

CAS Number

1110813-31-4

Synonyms

PF299804, PF299

Target

EGFR

Activity

Protein Tyrosine Kinase

Molecular Formula

C24H25ClFN5O2

Storage Conditions

2 years -80 in solvent