MS023

• Description :

  MS023, a chemical probe, is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].

• CAS Number :

  [1831110-54-3]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MS023.html

• Purity :

  99.93

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CN(CCN)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2

• Molecular Formula :

  C17H25N3O

• Molecular Weight :

  287.40

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11 (3) :772-81.|[2]Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134 (15) :1257-1268.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PRMT1; PRMT3; PRMT6; PRMT8