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Spindlin 1 Polyclonal Antibody

CAT: 0498-bs-0724RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-0724RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551) . Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006) . May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Synonyms
SPIN; Spindlin-1; Ovarian cancer-related protein; Spindlin1; SPIN1; OCR
Gene ID
10927
Swiss Prot
Q9Y657
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Immunogen
3-100/237
Target
Spindlin 1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Spindin 1
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Specificity
There is 60% sequence similarity with Spindlin 3, but the sequence is not continuous so the chance of bindin is low.
Gene ID URL
10927
Predicted Cross Reactivity
Mouse, Rat

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