CD272 Polyclonal Antibody

CAT: 0498-bs-0624RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-0624RSize:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T (H) 1) but not T (H) 2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2) -containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2) . BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) .
Synonyms
BTLA1; CD272; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA
Gene ID
151888
Swiss Prot
Q7Z6A9
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
221-289/289
Target
CD272
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human B and T-lymphocyte attenuator
Applications
WB, ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
151888

Related Products

CatalogName
BIO0578SM-1mgAnti-human BTLA / CD272 (Icatolimab Biosimilar)
BIO0578SM-20mgAnti-human BTLA / CD272 (Icatolimab Biosimilar)
BIO0578SM-5mgAnti-human BTLA / CD272 (Icatolimab Biosimilar)
bs-102197P-01Recombinant Human CD272/BTLA Protein, C-His
bs-1481RCD22 Polyclonal Antibody
bs-2491RCD27 Polyclonal Antibody
bs-23615RCD27 Polyclonal Antibody
bs-7492RPLXNC1/CD232 Polyclonal Antibody
bs-11019R-01B7-H3/CD276 Polyclonal Antibody
bs-11019R-TRB7-H3/CD276 Polyclonal Antibody

Alternative Products

CatalogName
MBS2555018-01CD272 Polyclonal Antibody
MBS9512390-01CD272 Rabbit Polyclonal Antibody

Popular Products