CP-673451

CAT: 0957-S1536-01Size: 5 mgDry Ice: YesHazardous: No

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CAT#:0957-S1536-01Size:5 mg

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Description

CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.

CAS Number

343787-29-1

Target

PDGFR

Activity

Protein Tyrosine Kinase

Molecular Formula

C24H27N5O2

Storage Conditions

2 years -80 in solvent

Chemical Information

CP-673451

1-[2-[5-(2-methoxyethoxy)-1-benzimidazolyl]-8-quinolinyl]-4-piperidinamine is an aminoquinoline.

CAS Number	343787-29-1
PubChem CID	10158940
IUPAC Name	1-[2-[5-(2-methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
Molecular Formula	C24H27N5O2
Molecular Weight	417.5
XLogP	3.3
Topological Polar Surface Area	78.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Heavy Atom Count	31
Formal Charge	0
Complexity	572

SMILES

COCCOC1=CC2=C(C=C1)N(C=N2)C3=NC4=C(C=CC=C4N5CCC(CC5)N)C=C3

InChI

InChI=1S/C24H27N5O2/c1-30-13-14-31-19-6-7-21-20(15-19)26-16-29(21)23-8-5-17-3-2-4-22(24(17)27-23)28-11-9-18(25)10-12-28/h2-8,15-16,18H,9-14,25H2,1H3

InChIKey

DEEOXSOLTLIWMG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 343787-29-1

CID: 10158940

Formula: C24H27N5O2

MW: 417.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	417.5
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	417.21647512
Monoisotopic Mass	417.21647512
Topological Polar Surface Area	78.4 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	572
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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S6177-01	CP 43
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Alternative Products

Catalog	Name
B1337-1	CP-673451
MBS132201-01	CP 673451
A11350-5	CP-673451 5mg
A11350-100	CP-673451 100mg
A11350-25	CP-673451 25mg
A11350-2	CP-673451 2mg
A11350-1	CP-673451 1mg

CP-673451

Chemical Information

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