SP600125

CAT: 0957-S1460-02Size: 10 mm/ 1 mLDry Ice: YesHazardous: No

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CAT#:0957-S1460-02Size:10 mm/ 1 mL

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Description

SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A, FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.

CAS Number

129-56-6

Synonyms

Nsc75890

Target

JNK

Activity

MAPK

Molecular Formula

C14H8N2O

Storage Conditions

2 years -80 in solvent

Chemical Information

anthra(1,9-cd)pyrazol-6(2H)-one

Anthra[1,9-cd]pyrazol-6(2H)-one is a member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase. It has a role as a geroprotector, an antineoplastic agent and a c-Jun N-terminal kinase inhibitor. It is a cyclic ketone, an aromatic ketone and an anthrapyrazole.

CAS Number	129-56-6
PubChem CID	8515
IUPAC Name	14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one
Molecular Formula	C14H8N2O
Molecular Weight	220.23
XLogP	2.7
Topological Polar Surface Area	45.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	17
Formal Charge	0
Complexity	343

SMILES

C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O

InChI

InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)

InChIKey

ACPOUJIDANTYHO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 129-56-6

CID: 8515

Formula: C14H8N2O

MW: 220.23

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	220.23
XLogP3	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	220.063662883
Monoisotopic Mass	220.063662883
Topological Polar Surface Area	45.8 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	343
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS565499-01	SP600125

SP600125

Chemical Information

Alternative Products

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