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YM201636

CAT: 0957-S1219-03Size: 25 mgDry Ice: YesHazardous: No
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CAT#:0957-S1219-03Size:25 mg
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Description
YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue) . YM-201636 suppresses the growth of liver cancer via the induction of autophagy.
CAS Number
371942-69-7
Target
PIKfyve
Activity
PI3K/Akt/mTOR
Molecular Formula
C25H21N7O3
Storage Conditions
2 years -80 in solvent

Chemical Information

YM-201636

6-amino-N-[3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenyl]-3-pyridinecarboxamide is an aromatic amide.

CAS Number371942-69-7
PubChem CID9956222
IUPAC Name6-amino-N-[3-(6-morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl)phenyl]pyridine-3-carboxamide
Molecular FormulaC25H21N7O3
Molecular Weight467.5
XLogP2.5
Topological Polar Surface Area132
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity738
SMILES
C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)NC(=O)C6=CN=C(C=C6)N
InChI
InChI=1S/C25H21N7O3/c26-19-7-6-16(14-28-19)24(33)29-17-4-1-3-15(13-17)22-30-20-18-5-2-8-27-25(18)35-21(20)23(31-22)32-9-11-34-12-10-32/h1-8,13-14H,9-12H2,(H2,26,28)(H,29,33)
InChIKey
YBPIBGNBHHGLEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of YM-201636
CAS: 371942-69-7
CID: 9956222
Formula: C25H21N7O3
MW: 467.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight467.5
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass467.17058756
Monoisotopic Mass467.17058756
Topological Polar Surface Area132 Ų
Heavy Atom Count35
Formal Charge0
Complexity738
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B2189-5.1YM201636
A11064-50YM201636 50mg
A11064-25YM201636 25mg
A11064-500YM201636 500mg
A11064-2YM201636 2mg
GW7605-10mgYM201636 hydrochloride
A11064-100YM201636 100mg
A11064-10YM201636 10mg
A11064-5YM201636 5mg
A11064-1YM201636 1mg

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