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PD98059

CAT: 0957-S1177-01Size: 10 mgDry Ice: YesHazardous: No
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CAT#:0957-S1177-01Size:10 mg
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Description
PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.
CAS Number
167869-21-8
Target
MEK
Activity
Protein Tyrosine Kinase
Molecular Formula
C16H13NO3
Storage Conditions
2 years -80 in solvent

Chemical Information

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

2-(2-amino-3-methoxyphenyl)chromen-4-one is a member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'. It has a role as a geroprotector and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a monomethoxyflavone and an aromatic amine.

CAS Number167869-21-8
PubChem CID4713
IUPAC Name2-(2-amino-3-methoxyphenyl)chromen-4-one
Molecular FormulaC16H13NO3
Molecular Weight267.28
XLogP2.9
Topological Polar Surface Area61.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity407
SMILES
COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
InChI
InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChIKey
QFWCYNPOPKQOKV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
CAS: 167869-21-8
CID: 4713
Formula: C16H13NO3
MW: 267.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight267.28
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass267.08954328
Monoisotopic Mass267.08954328
Topological Polar Surface Area61.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity407
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A1663-5PD98059
A10705-5PD98059 5mg
A10705-10PD98059 10mg
A10705-500PD98059 500mg

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