Products for Research Use Only
RegisterLogin

Vandetanib

CAT: 0957-S1046-01Size: 25 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0957-S1046-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS) .
CAS Number
443913-73-3
Synonyms
ZD6474
Target
VEGFR
Activity
Protein Tyrosine Kinase
Molecular Formula
C22H24BrFN4O2
Storage Conditions
2 years -80 in solvent

Alternative Products

CatalogName
FV28668-01Vandetanib

Popular Products