Bis-T-23

Bis-T-23

• Product Name Alternative: AG1717
• CAS Number: 171674-76-3
• UNSPSC Description: Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].
• Target Antigen: Dynamin; HIV Integrase
• Type: Reference compound
• Related Pathways: Cytoskeleton;Metabolic Enzyme/Protease
• Field of Research: Infection; Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/bis-t-23.html
• Purity: 96.07
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(/C(C#N)=C/C1=CC(O)=C(C(O)=C1)O)NCCCNC(/C(C#N)=C/C2=CC(O)=C(C(O)=C2)O)=O
• Molecular Weight: 480.43
• References & Citations: [1]Schiffer M, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21(6):601-609.|[2]Mazumder, A.,et al. Effects of Tyrphostins, Protein Kinase Inhibitors, on Human Immunodeficiency Virus Type 1 Integrase. Biochemistry, 1995, 34(46), 15111–15122.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported