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Niclosamide ethanolamine

CAT: 0957-E6051-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0957-E6051-01Size:100 mg
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Description
Niclosamide ethanolamine (Niclosamide-olamine, BAY2353 olamine) is a mild mitochondrial uncoupler, anthelmintic agent, and highly potent inhibitor of STAT3 signaling pathway with an IC50 of 0.25 μM. It improves insulin levels, body weight, and muscle wasting, inhibits artery constriction, suppresses PI3K-mTORC1 signaling to block fibroblast proliferation, inhibits TGF-β1-induced EMT and ECM accumulation via the mTORC1-4EBP1 axis, activates noncanonical autophagy to sensitize fibroblasts to apoptosis, and confers renoprotection in diabetic and adriamycin-induced nondiabetic kidney disease models.
CAS Number
1420-04-8
Synonyms
Niclosamide-olamine, BAY2353 olamine
Target
STAT
Activity
Apoptosis
Molecular Formula
C13H8Cl2N2O4.C2H7NO

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