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PU139

CAT: 0957-E5829-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E5829-01Size:5 mg
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Description
PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits anticancer activity.
CAS Number
158093-65-3
Target
Histone Acetyltransferase
Activity
Epigenetics
Molecular Formula
C12H7FN2OS

Chemical Information

2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
CAS Number158093-65-3
PubChem CID9992116
IUPAC Name2-(4-fluorophenyl)-[1,2]thiazolo[5,4-b]pyridin-3-one
Molecular FormulaC12H7FN2OS
Molecular Weight246.26
XLogP2.4
Topological Polar Surface Area58.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity307
SMILES
C1=CC2=C(N=C1)SN(C2=O)C3=CC=C(C=C3)F
InChI
InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
InChIKey
QMCIVCACYJRAAY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
CAS: 158093-65-3
CID: 9992116
Formula: C12H7FN2OS
MW: 246.26
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight246.26
XLogP32.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass246.02631219
Monoisotopic Mass246.02631219
Topological Polar Surface Area58.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity307
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4767-10PU139

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