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FDW028

CAT: 0957-E4732-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0957-E4732-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FDW028 is a highly potent and selective inhibitor of FUT8. FDW028 demonstrates strong anti-tumor effects by promoting defucosylation and inducing lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway. Additionally, FDW028 suppresses the AKT/mTOR signaling pathway. FDW028 exhibits potent anti-Metastatic colorectal cancer (mCRC) activities.
CAS Number
2768426-49-7
Target
Others
Activity
Others
Molecular Formula
C22H24N6O

Chemical Information

5-((Benzylamino)methyl)-2-((4-ethylbenzyl)amino)-[1,2,4]triazolo[1,5-A]pyrimidin-7-OL
CAS Number2768426-49-7
PubChem CID53208107
IUPAC Name5-[(benzylamino)methyl]-2-[(4-ethylphenyl)methylamino]-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
Molecular FormulaC22H24N6O
Molecular Weight388.5
XLogP2.1
Topological Polar Surface Area81.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Heavy Atom Count29
Formal Charge0
Complexity671
SMILES
CCC1=CC=C(C=C1)CNC2=NC3=NC(=CC(=O)N3N2)CNCC4=CC=CC=C4
InChI
InChI=1S/C22H24N6O/c1-2-16-8-10-18(11-9-16)14-24-21-26-22-25-19(12-20(29)28(22)27-21)15-23-13-17-6-4-3-5-7-17/h3-12,23H,2,13-15H2,1H3,(H2,24,25,26,27)
InChIKey
PAWBAUIXKSTNNX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-((Benzylamino)methyl)-2-((4-ethylbenzyl)amino)-[1,2,4]triazolo[1,5-A]pyrimidin-7-OL
CAS: 2768426-49-7
CID: 53208107
Formula: C22H24N6O
MW: 388.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.5
XLogP32.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass388.20115941
Monoisotopic Mass388.20115941
Topological Polar Surface Area81.1 Ų
Heavy Atom Count29
Formal Charge0
Complexity671
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C03314-5mgFDW028

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