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DCZ0415

CAT: 0957-E4686-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E4686-01Size:5 mg
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Description
DCZ0415 is a potent inhibitor of TRIP13. DCZ0415 impairs nonhomologous end joining repair and inhibits NF-κB activity. It triggers anti-myeloma effects both in vitro, and in vivo, and primary cells obtained from myeloma patients resistant to drugs.
CAS Number
2242470-43-3
Target
THR
Activity
Endocrinology & Hormones
Molecular Formula
C23H20N2O2

Chemical Information

2-(4-(Pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS Number2242470-43-3
PubChem CID145925662
IUPAC Name4-[4-(pyridin-4-ylmethyl)phenyl]-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione
Molecular FormulaC23H20N2O2
Molecular Weight356.4
XLogP3
Topological Polar Surface Area50.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity638
SMILES
C1C2C1C3C=CC2C4C3C(=O)N(C4=O)C5=CC=C(C=C5)CC6=CC=NC=C6
InChI
InChI=1S/C23H20N2O2/c26-22-20-16-5-6-17(19-12-18(16)19)21(20)23(27)25(22)15-3-1-13(2-4-15)11-14-7-9-24-10-8-14/h1-10,16-21H,11-12H2
InChIKey
LOXMLWHUIONWMI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-(Pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS: 2242470-43-3
CID: 145925662
Formula: C23H20N2O2
MW: 356.4
Interactive 3D Structure
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Computed Properties
PropertyValue
Molecular Weight356.4
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass356.152477885
Monoisotopic Mass356.152477885
Topological Polar Surface Area50.3 Ų
Heavy Atom Count27
Formal Charge0
Complexity638
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count6
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA2771-50DCZ0415

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