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Rezivertinib

CAT: 0957-E4675-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E4675-01Size:5 mg
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Description
Rezivertinib (BPI-7711) is a potent third-generation inhibitor of EGFR tyrosine kinase, targeting both EGFR-sensitizing mutations and the EGFR T790M mutation. Additionally, it has excellent CNS penetration and has antitumor activity.
CAS Number
1835667-12-3
Synonyms
BPI-7711
Target
EGFR
Activity
Protein Tyrosine Kinase
Molecular Formula
C27H30N6O3

Chemical Information

Rezivertinib

Rezivertinib is a small molecule drug. The usage of the INN stem '-ertinib' in the name indicates that Rezivertinib is a epidermal growth factor receptor (EGFR) inhibitor. Rezivertinib is under investigation in clinical trial NCT06955325 (Umbrella Trial of Adjuvant Therapy in Completely Resected High-risk Stage IA-IB NSCLC: Focus on Driver Mutations). Rezivertinib has a monoisotopic molecular weight of 486.24 Da.

CAS Number1835667-12-3
PubChem CID118912975
IUPAC NameN-[2-[2-(dimethylamino)ethoxy]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
Molecular FormulaC27H30N6O3
Molecular Weight486.6
XLogP3.6
Topological Polar Surface Area93.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count36
Formal Charge0
Complexity724
SMILES
CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=CC(=C(C=C4OC)OCCN(C)C)NC(=O)C=C
InChI
InChI=1S/C27H30N6O3/c1-6-26(34)29-22-15-21(24(35-5)16-25(22)36-14-13-32(2)3)31-27-28-12-11-20(30-27)19-17-33(4)23-10-8-7-9-18(19)23/h6-12,15-17H,1,13-14H2,2-5H3,(H,29,34)(H,28,30,31)
InChIKey
BPMZUKYFIDPLEA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Rezivertinib
CAS: 1835667-12-3
CID: 118912975
Formula: C27H30N6O3
MW: 486.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight486.6
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass486.23793884
Monoisotopic Mass486.23793884
Topological Polar Surface Area93.5 Ų
Heavy Atom Count36
Formal Charge0
Complexity724
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
KYC66712-01Rezivertinib
HY-148053-01Rezivertinib analogue 1
HY-148053R-01Rezivertinib analogue 1 (Standard)
A24174-500Rezivertinib (BPI-7711) 500mg
A24174-250Rezivertinib (BPI-7711) 250mg

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