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Zavondemstat

CAT: 0957-E1819-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E1819-02Size:5 mg
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Description
Zavondemstat (QC8222, TACH 101) is a small-molecule pan-inhibitor of histone lysine demethylase 4D (KDM4D) that selectively targets KDM4A-D with no effect on other KDM families. It exhibits potent antiproliferative activity in various cancer cell lines and organoid models. It displays antineoplastic activity and acts as a potential anticancer agent.
CAS Number
1851412-93-5
Synonyms
QC8222; TACH 101
Target
Histone Demethylase
Activity
Epigenetics
Molecular Formula
C26H29N3O3

Chemical Information

Zavondemstat

Zavondemstat is a small molecule drug. The usage of the INN stem '-demstat' in the name indicates that Zavondemstat is a Lysine-specific histone demethylase inhibitor. Zavondemstat has a monoisotopic molecular weight of 431.22 Da.

CAS Number1851412-93-5
PubChem CID118597685
IUPAC Name3-[[(4R)-7-(N-methyl-4-propan-2-ylanilino)-3,4-dihydro-2H-chromen-4-yl]methylamino]pyridine-4-carboxylic acid
Molecular FormulaC26H29N3O3
Molecular Weight431.5
XLogP5.6
Topological Polar Surface Area74.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity607
SMILES
CC(C)C1=CC=C(C=C1)N(C)C2=CC3=C(C=C2)[C@@H](CCO3)CNC4=C(C=CN=C4)C(=O)O
InChI
InChI=1S/C26H29N3O3/c1-17(2)18-4-6-20(7-5-18)29(3)21-8-9-22-19(11-13-32-25(22)14-21)15-28-24-16-27-12-10-23(24)26(30)31/h4-10,12,14,16-17,19,28H,11,13,15H2,1-3H3,(H,30,31)/t19-/m0/s1
InChIKey
NDVITLLKZQXKGU-IBGZPJMESA-N
Chemical Structure
2D Structure
2D structure of Zavondemstat
CAS: 1851412-93-5
CID: 118597685
Formula: C26H29N3O3
MW: 431.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight431.5
XLogP35.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass431.22089180
Monoisotopic Mass431.22089180
Topological Polar Surface Area74.7 Ų
Heavy Atom Count32
Formal Charge0
Complexity607
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-148807-01Zavondemstat
HY-148807B-01(S) -Zavondemstat
TYD-03034-01Zavondemstat sodium
HY-148807CZavondemstat (sodium)
GTR19261503-01Zavondemstat L-lysine
HY-148807AZavondemstat (L-lysine)
A24500-10Zavondemstat (QC8222 free base) 10mg
A24500-50Zavondemstat (QC8222 free base) 50mg
A24500-5Zavondemstat (QC8222 free base) 5mg
A24500-1Zavondemstat (QC8222 free base) 1mg

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