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Tefinostat (CHR-2845)

CAT: 0957-E1554-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-E1554-01Size:1 mg
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Description
Tefinostat (CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase (HDAC) . Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat.
CAS Number
914382-60-8
Target
HDAC
Activity
DNA Damage/DNA Repair
Molecular Formula
C28H37N3O5

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