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MK-0159

CAT: 0957-E1276-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E1276-02Size:25 mg
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Description
MK-015 (Compound 37) is an inhibitor of CD38. MK-0159 inhibits human, mouse, and rat CD38 (cell-free assays) with IC50 values of 22, 3, and 70 nM, respectively. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart.
CAS Number
2641484-61-7
Synonyms
Compound 37
Target
CD markers
Activity
Transmembrane Transporters
Molecular Formula
C20H24N4O3S
Storage Conditions
3 years -20°C powder

Chemical Information

N-(trans-4-(2-Methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide
CAS Number2641484-61-7
PubChem CID156339417
IUPAC NameN-[4-(2-methoxyethoxy)cyclohexyl]-6-(1,3-thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide
Molecular FormulaC20H24N4O3S
Molecular Weight400.5
XLogP2.4
Topological Polar Surface Area117
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity518
SMILES
COCCOC1CCC(CC1)NC(=O)C2=CC(=NC3=C2C=CN3)C4=CN=CS4
InChI
InChI=1S/C20H24N4O3S/c1-26-8-9-27-14-4-2-13(3-5-14)23-20(25)16-10-17(18-11-21-12-28-18)24-19-15(16)6-7-22-19/h6-7,10-14H,2-5,8-9H2,1H3,(H,22,24)(H,23,25)
InChIKey
JUVJFMVGYBBDKN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(trans-4-(2-Methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide
CAS: 2641484-61-7
CID: 156339417
Formula: C20H24N4O3S
MW: 400.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight400.5
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass400.15691181
Monoisotopic Mass400.15691181
Topological Polar Surface Area117 Ų
Heavy Atom Count28
Formal Charge0
Complexity518
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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BUP02199-01MK-0159
A24359-50MK-0159 50mg
A24359-100MK-0159 100mg
A24359-10MK-0159 10mg
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