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HS-276

CAT: 0957-E1155-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E1155-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HS-276, a potent and highly selective orally bioavailable transforming growth factor-β activated kinase-1 (TAK1) inhibitor with the Ki and IC50 of 2.5 nM and 2.3 nM respectively, shows significant inhibition of TNF-mediated cytokine profiles, correlating with significant attenuation of arthritic-like symptoms in the collagen-induced arthritis (CIA) mouse model of inflammatory rheumatoid arthritis (RA) .
CAS Number
2767422-72-8
Target
TAK1
Activity
MAPK
Storage Conditions
3 years -20°C powder