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LDC195943 (IMT1)

CAT: 0957-E0443-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E0443-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT) . IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
CAS Number
2304621-31-4
Synonyms
IMT1
Target
DNA/RNA Synthesis
Activity
Cell Cycle
Molecular Formula
C21H21NO4
Storage Conditions
3 years -20°C powder

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