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Mebhydroline

CAT: 0957-E4873-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E4873-02Size:25 mg
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Description
Mebhydroline acts as a selective antagonist of farnesoid X receptor (FXR) . Mebhydrolin improves blood glucose balance in in vivo mice models by inhibiting hepatic gluconeogenesis through the FXR/miR-22-3p/PI3K/AKT/FoxO1 pathway and enhancing glycogen synthesis. It also acts as a specific antagonist of histamine H1 receptor. It has potential for its use in the treatment of Type 2 diabetes mellitus (T2DM) .
CAS Number
524-81-2
Target
FXR
Activity
Metabolism
Molecular Formula
C19H20N2

Chemical Information

Mebhydrolin

Mebhydrolin is a member of indoles.

CAS Number524-81-2
PubChem CID22530
IUPAC Name5-benzyl-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole
Molecular FormulaC19H20N2
Molecular Weight276.4
XLogP3.5
Topological Polar Surface Area8.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity349
SMILES
CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=CC=C4
InChI
InChI=1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
InChIKey
FQQIIPAOSKSOJM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mebhydrolin
CAS: 524-81-2
CID: 22530
Formula: C19H20N2
MW: 276.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight276.4
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass276.162648646
Monoisotopic Mass276.162648646
Topological Polar Surface Area8.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity349
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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