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JR14a

CAT: 0957-E1048-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E1048-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JR14a, a selective and potent human Complement C3a receptor antagonist, which is assessed by inhibition of intracellular calcium release (IC50=10 nM) induced in human monocyte-derived macrophages by C3a, inhibition of β-hexosaminidase secretion (IC50=8 nM) from human LAD2 mast cells degranulated by C3a, and selectivity for human C3aR over C5aR.
CAS Number
2411440-41-8
Target
Complement System
Activity
Immunology & Inflammation
Molecular Formula
C25H26Cl2N4O3S
Storage Conditions
3 years -20°C powder