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Hydroxyfasudil HCl

CAT: 0957-S8208-02Size: 25 mgDry Ice: YesHazardous: No
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CAT#:0957-S8208-02Size:25 mg
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Description
Hydroxyfasudil HCl, an active metabolite of fasudil hydrochloride, is a specific Rho-kinase (ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively.
CAS Number
155558-32-0
Synonyms
HA-1100
Target
ROCK
Activity
Cytoskeletal Signaling
Molecular Formula
C14H17N3O3S·HCl·xH2O
Storage Conditions
2 years -80 in solvent

Chemical Information

Hydroxyfasudil monohydrochloride
CAS Number155558-32-0
PubChem CID11371328
IUPAC Name5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one;hydrochloride
Molecular FormulaC14H18ClN3O3S
Molecular Weight343.8
Topological Polar Surface Area86.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity526
SMILES
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
InChI
InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
InChIKey
XWWFOUVDVJGNNG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hydroxyfasudil monohydrochloride
CAS: 155558-32-0
CID: 11371328
Formula: C14H18ClN3O3S
MW: 343.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass343.0757403
Monoisotopic Mass343.0757403
Topological Polar Surface Area86.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity526
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
A3478-5.1Hydroxyfasudil
A3479-10Hydroxyfasudil hydrochloride
HY-13911A-01Hydroxyfasudil (hydrochloride)
C13266-25mgHydroxyfasudil HCl
A15118-100Hydroxyfasudil 100mg
A15118-25Hydroxyfasudil 25mg
A15118-10Hydroxyfasudil 10mg
A15118-5Hydroxyfasudil 5mg

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