GDC-0349

CAT: 0957-S8040-01Size: 5 mgDry Ice: YesHazardous: No

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CAT#:0957-S8040-01Size:5 mg

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Description

GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.

CAS Number

1207360-89-1

Synonyms

RG-7603

Target

MTOR

Activity

PI3K/Akt/mTOR

Molecular Formula

C24H32N6O3

Storage Conditions

2 years -80 in solvent

Chemical Information

Gdc-0349

GDC-0349 has been used in trials studying the treatment of Non-Hodgkin's Lymphoma, Solid Tumor.

CAS Number	1207360-89-1
PubChem CID	59239165
IUPAC Name	1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea
Molecular Formula	C24H32N6O3
Molecular Weight	452.5
XLogP	1.4
Topological Polar Surface Area	91.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	33
Formal Charge	0
Complexity	656

SMILES

CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C

InChI

InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1

InChIKey

RGJOJUGRHPQXGF-INIZCTEOSA-N

Chemical Structure

2D Structure

CAS: 1207360-89-1

CID: 59239165

Formula: C24H32N6O3

MW: 452.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	452.5
XLogP3	1.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	452.25358890
Monoisotopic Mass	452.25358890
Topological Polar Surface Area	91.9 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	656
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA3639-5	GDC-0349
A11443-5	GDC-0349 5mg
A11443-2	GDC-0349 2mg
MBS132459-01	GDC-0349, RG7603
A11443-25	GDC-0349 25mg

GDC-0349

Chemical Information

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